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Only Natural Berberine 1000 - 50 Vegetarian Capsules - eVitamins SingaporeAdding Cart... Added to the car Not added The item is in your cart Not added Sorry, there was a problem. Sorry, there was a problem. Image not available Berberine HCL 500mg, Powerful AMPK Activator, Blood Sugar Support (Vegetarian, gluten free, non-OMG) Complex Extract Supplement, 60 capsules per Double Wood Supplements Article form Capsuula Brand brand Double wood supplements Ingredients Active ingredients: Berberina - 500mg Other ingredients: Silocon Dioxide, Gelatin Information about allergens Gluten Free Weight of the article 1.5 ounces On this item - I'm sorry. [Engine] Do you have any questions? Find answers in product information, Q pestAs, reviews Your question can be answered by sellers, manufacturers or customers who bought this product. Please make sure you are posting in the form of a question. Please enter a question. Product Description Berberine HCL (HCI) (Hydrochloride) The extract is a quaternary ammonia salt from the protoberine group of isoquinoline alkaloids. It is commonly found in many natural plants, including raspberry, gold and gold. Studies have shown a dose of 500 mg taken 3 times a day can help regulate blood sugar, insulin and contribute to weight loss, as well as provide other health benefits. Berberine is considered an active PK which means it acts as a metabolic power amplifier activator. Our complex Berberine supplement is sold in capsule form 500 mg. (1,500 portions space size out of the day, as only 500 mg should be taken at a time). It is manufactured within the U.S. in a GMP certified installation and purity tests can be performed on request. Product details VideosVideos for this product 0:20 Click to play video Beberine HCL capsules for double wood supplements Important information Security information Check your doctor before using this product. Do not consume more than 4 capsules a day. Do not take this product if you are pregnant, breastfeeding or taking other medicines. Decontinue your use and consult your doctor immediately if adverse reactions occur. Do not take Berberine and operate heavy machinery until you know how it affects you. Stay out of reach of children. Side effects include headaches, nausea, stomach cramps and diarrheaIndicationsNON-GMO and GLUTEN LIBREIngredients Active ingredients: Berberine - 500mg Other ingredients: Silocon Dioxide, GelatinaDirections Take 2-4 capsules per day, divided into 2-4 discrete doses. Berberine should be taken along with or directly after a meal to maximize its beneficial effect on blood glucose levels. Legal DisclaimerDeclarations regarding dietary supplements have not been evaluated by FDA and are not intended to diagnose, treat, cure or prevent any disease or health condition. Products related to this article .sp_detail2_sponsored_label { color: #555555; font-size: 11px; } .sp_detail2_info_icon { width: 11px; vertical-align: text-bottom; fill: #96969696; } belsp_info_link { text-decoration:none !important] Images of customers Top American Reviews There was a problem leaking opinions right now. Please try later. There's a problem loading this menu right now. Disclaimer: While we work to ensure that the product information is correct, manufacturers may sometimes alter their lists of ingredients. Real product packaging and materials may contain more and/or different information than is shown on our website. We recommend that you not only trust the information presented and always read labels, warnings and addresses before using or consuming a product. For more information on a product, please contact the manufacturer. The content on this site is for reference purposes and is not intended to replace the advice given by a doctor, pharmacist or other licensed health professional. You should not use this information as a self-diagnosis or to treat a health or disease problem. Contact your health care provider immediately if you suspect you have a medical problem. The Food and Drug Administration has not assessed information and statements relating to dietary supplements and are not intended to diagnose, treat, cure or prevent any disease or health condition. Amazon.com assumes no liability for inaccuracies or errors on products.

RELATED TO VITAMINS ' SUPPLEMENTS BERBERINE Synopsis How does it work? Uses " Effectiveness " Possibly effective for insufficient tests for side effects When taken by mouthPOSSIBLY SAFEWhen applied to the skinSpecial precautions and warnings of SAFE FOS Pregnancy and natural breastfeeding UNSAFELIKELY UNSAFEChildrenLIKELY UNSAFEDiabetes High levels of bilirubine in the blood Berberine may decrease how quickly the body breaks down the cyclosporine (Neoral, Sandimmune). This may cause too much cyclosporine (Neoral, Sandimmune) to be in the body and potentially cause side effects. Moderate interaction Beware of this combination The drugs changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interact with BERBERINE Some medicines are changed and decomposed by the liver. Berberine may decrease how quickly the liver breaks down some medications. Taking berberine along with some medicines that are broken down by the liver may increase the side effects and effects of some medications. Before taking berberine, talk to your health care provider if you are taking any medication that is changed by the liver. Some medicines changed by the liver include cyclosporine (Neoral, Sandimmune), lovastatin (Mevacor), claritromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), and many others. MOUTH ADULTSBY:For diabetes For high levels of cholesterol or other fats (lipids) in the blood (hyperlipemia)For high blood pressure For a hormonal disorder that causes the ovaries enlarged with cysts (polychi ovary syndrome or PCOS)APPLIED TO THE SKIN:For the cánker Afube, F. Evaluation of some Mexican plants for their trippanocidal activity and active components in Guaco, roots of Aristólochia taliscana. Biol Pharm Bull 2002;25(9):1188-1191. See summary. Affuso, F., Ruvolo, A., Micillo, F., Sacca, L. and Fazio, S. Effects of a nutraceutical combination (berberine, red yeast rice and polycosanols) in lipid levels and randomized endothelial function, double-blind, placebo-controlled study. Nutr Metab Cardiovasc. Dis 2010;20(9):656-661. See summary. Albal, M. V., Jadhav, S. and Chandorkar, A. G. Clinical evaluation of berberine in mycotic infections. Indian J Ophthalmol. 1986;34:91-92. See summary. Arana, B. A., Navin, T. R., Arana, F. E., Berman, J. D. and Rosenkaimer, F. Effectiveness of a short course (10 days) of high-dose meglumina antimonate with or without interferon-gamma in the treatment of skin leishmaniasis in Guatemala. Clin Infect Dis 1994;18(3):381-384. See summary. Babbar, O. P., Chhatwal, V. K., Ray, I. B. and Mehra, M. K. Effect of Berberin Chloride Drops in Clinically Positive Tracoma Patients. Indian J Med Res. 1982;76 Suppl:83-88. See summary. Berberine. Med Rev 2000;5(2):175-177. See summary. Carlomagno, G., Pirozzi, C., Mercury, V., Ruvolo, A., and Fazio, S. Effects of a nutraceutical combination on left ventricular remodeling and vasoreactivity in subjects with metabolic syndrome. Nutr Metab Cardiovasc. Dis 2012;22(5):e13-e14. See summary. Chae, S. H., Jeong, I. H., Choi, D. H., Oh, J. W., and Ahn, Y. J. Effects of inhibition of growth of Coptis isoquinoline japonica of isoquinolin origin on human intestinal bacteria. J Agric. Chem food 1999;47(3):934-938. See summary. Chekalina, S. I., Umurzakova, R. Z., Saliev, K. K., and Abdurakhmanov, T. R. [Berberine bisulphate effect on platelet hemostasis in thrombocytopenia patients]. Gematologiia i Transfuziologiia 1994;39(5):33-35. See summary. Choudhry, V.P., Sabir, M., and Bhide, V. N. Berberine in giardiasis. Indian Pediatr. 1972;9(3):143-146. See summary. Chun YT, Yip TT, Lau KL, and et al. A biochemical study on the hypotensive effect of berberine in rats. Gen Pharmac 1979;10:177-182. See summary. Chung JG, Wu LT, Chang SH and others. Brberine inhibitory actions on growth and arylamine N-acetyransferase activity in Helicobacter Pylori strains of patients with peptic ulcer. International Journal of Toxicology 1999;18:35. Chung, J. G., Chen, G. W., Hung, C. F., Lee, J. H., Ho, C., Ho, H. C., Chang, H. L., Lin, W. C. and Lin, J. G. Effects of berberine on arylamine N-acetyltransferase activity and 2-aminofluorene-DNA adduct cells. Am J Chin Med 2000;28(2):227-238. See summary. Chung, J. G., Wu, L. T., Chu, C. B., Jan, J. Y., Ho, C. C., Tsou, M. F., Lu, H. F., Chen, G. W., Lin, J. G., and Wang, T. F. Effects of berberine on arylamine N-acetyltransferase activity in human cells. Food Chem Toxicol 1999;37(4):319-326. See summary. Cianci, A., Cicero, A. F., Colacurci, N., Matarazzo, M. G., and De, Leo, V. Isoflavones and Berberine activity on vasomotor symptoms and lipid profile in menopausian women. Gynecol.Endocrinol. 2012;28(9):699-702. See summary. Desai, A. B., Shah, K. M. and Shah, D. M. Berberine in treatment of diarrhea. Indian Pediatr. 1971;8(9):462-465. See summary. Dutta NK and Panse MV. Utility of Berberin (alkaloids of Berberis aristata) in the treatment of cholera (experimental). India J Med Res 1962;50(5):732-736. Freile, M. L., Giannini, F., Pucci, G., Sturniolo, A., Rodero, L., Pucci, O., Balzareti, V. and Enriz, R. D. Antimicrobial activity of aqueous extracts and berberine isolated from Berberine heterofila. Physiotherapy 2003;74(7-8):702-705. See summary. Fukuda, K., Hibiya, Y., Mutoh, M., Koshiji, M., Akao, S., and Fujiwara, H. Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. J Ethnopharmacol. 1999;66(2):227-233. See summary. Ghosh AK, Bhattacharyya FK, and Ghosh DK. Leishmania donovani: Breast inhibition and Berberine action mode. Experimental parasitology 1985;60:404-413. Guo, Yes, Chen, Y., Tan, Z. R., Klaassen, C.D. and Zhou, H. H. The repeated administration of Berberine inhibits cytochrome P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. See summary. Hajnicka, V., Kost'alova, D., Svecova, D., Sochorova, R., Fuchsberger, N., and Toth, J. Effect of Mahonia aquifolium active compounds on interleukin-8 production in the human monocytic cell line THP-1. Med Plant 2002;68(3):266-268. See summary. Hayasaka, S., Kodama, T., and Ohira, A. Traditional Japanese herb medicines (kampo) and treatment of eye diseases: a review. Am J Chin Med 2012;40(5):887-904. See summary. Hermann, R. and von, Richter O. Clinical testing of herbal drugs as authors of drug interactions. Med Plant 2012;78(13):1458-1477. See summary. Holick, M. F., Lamb, J. J., Lerman, R. H., Konda, V. R., Darland, G., Minich, D. M., Desai, A., Chen, T. C., Austin, M., Kornberg, J., Chang, J. L., Hsi, A., Bland, J. S. and Tripp. J Bone Miner.Metab 2010;28(3):342-350. See summary. Hong, Y., Hui, S., Chan, B. T. and Hou, J. Effect of Berberine on catecholamine levels in rats with experimental cardiac hypertrophy. Life Sci. 4-18-2003;72(22):2499-2507. See summary. Hu, F. L. [Comparison of acid and Helicobacter pylori in ulcerogenesis of duodenal ulcer disease]. Zhonghua Yi.Xue.Za Zhi. 1993;73(4):217-9, 253. See summary. Hu, J. P., Takahashi, N., and Yamada, T. Coptidis rhizoma inhibits the growth and proteases of oral bacteria. Oral Dis. 2000;6(5):297-302. See summary. Hu, Y., Ehli, E. A., Kittelsrud, J., Ronan, P. J., Munger, K., Downey, T., Bohlen, K., Callahan, L., Munson, V., Jahnke, M., Marshall, L., Nelson, K., Huizenga, P., Hansen, R., J., Soundy, Tine, T. Fitomedicine. 7-15-2012;19(10):861-867. See summary. Huang, W. [Extension tachyarritmias ventricular treated with berberine]. Zhonghua Xin.Xue.Guan.Bing.Za Zhi. 1990;18(3):155-6, 190. See summary. Huang, W. M., Wu, Z. D., and Gan, Y. Q. [Berberine Effects on Ischemic Ventricular Arrhythmia]. Zhonghua Xin.Xue.Guan.Bing.Za Zhi. 1989;17(5):300-1, 319. See summary. Hui, K. K., Yu, J. L., Chan, W. F. and Tse, E. Berberine interaction with human platelet adherents alpha 2. Life Sci. 1991;49(4):315-324. See summary. Iizuka, N., Miyamoto, K., Okita, K., Tangoku, A., Hayashi, H., Yosino, S., Abe, T., Morioka, T., Hazama, S., and Oka, M. Inhibitory effect of Coptidis Rhizoma and Berberine on the proliferation of lines of human esophagus cancer cells. Cancer Lett 1-1-2000;148(1):19-25. See summary. Iizuka, N., Oka, M., Yamamoto, K., Tangoku, A., Miyamoto, K., Miyamoto, T., Uchimura, S., Hamamoto, Y., and Okita, K. Identification of common or different genes related to antitumor activities of a medicinal herb and its main component by oligonucleotid microarrayo. Int J Cancer 11-20-2003;107(4):666-672. See summary. Inbaraj, J. J., Kukielczak, B. M., Bilski, P., Sandvik, S. L. and Chignell, C. F. Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.) 1. Berberine. Chem Res Toxicol 2001;14(11):1529-1534. See summary. Inoue, K., Kulsum, U., Chowdhury, S.A., Fujisawa, S., Ishihara, M., Yokoe, I., and Sakagami, H. Tumor-specifictotoxicity and apoptosis-inducing activity of berberines. Anticancer Res 2005;25(6B):4053-4059. See summary. Jantova, S., Cipak, L., Cernakova, M., and Kost'alova, D. Effect of Berberine on proliferation, cell cycle and apoptosis in HeLa and L1210 cells. J Pharm Pharmacol 2003;55(8):1143-1149. See summary. Jeong, H. W., Hsu, K. C., Lee, J. W., Ham, M., Huh, J. Y., Shin, H. J., Kim, W. S. and Kim, J. B. Berberine suppresses proinflammatory responses through the activation of AMPK in macrophages. Am J Physiol Endocrinol. Metab 2009;296(4):E955-E964. See summary. Kamat SA. Clinical trials with Berberin hydrochloride for diarrhea control in acute gastroenteritis. J Assoc Physicians India 1967;15:525-529. Kaneda Y, Tanaka T, and Saw T. Effects of Berberine, an alkaloid plant, in the growth of anaerobic protozoa in axenic culture. Tokai J Exp Clin Med 1990;15(6):417-423. Kaneda Y, Torii M, Tanaka T, and et al. In vitro effects of berberine sulfate on the growth and structure of the histolytics of Entamoeba, Giardia lamblia and Trichomonas vaginalis. Annals of Tropical Medicine and Parasitology 1991;85(4):417-425. Khin, Maung U. and Nwe, Nwe Wai. Effect of berberine in the accumulation of intestinal fluid induced by enterotoxin in rats. J Diarrestreal Dis Res 1992;10(4):201-204. See summary. Khin, Maung U., Myo, Khin, Nyunt, Nyunt Wai and Tin, U. High-dose and tetracycline clinical trial in cholera. J Diarrestrel Dis Res 1987;5(3):184-187. See summary. Khin, Maung U., Myo, Khin, Nyunt, Nyunt Wai, Aye, Kyaw and Tin, U. Clinical berberine testing in acute aqueous diarrhea. Br.Med.J.(Clin.Res.Ed) 12-7-1985;291(6509):1601-1605. See summary. Kim, H. S., Kim, M. J., Kim, E. J., Yang, Y., Lee, M. S. and Lim, J. S. The AMPK activation induced by Berberine inhibits the metastatic potential of melanoma cells by reducing ERK activity and COX-2 protein expression. Biochem. Pharmacol 2-1-2012;83(3):385-394. See summary. Kim, W. S., Lee, Y. S., Cha, S. H., Jeong, H. W., Choe, S., Lee, M. R., Oh, G. T., Park, H. S., Lee, K. U., Lane, M. D., and Kim, J. B. Berberine improves the disregulation of lipids in central activity Metab 2009;296(4):E812-E819. See summary. Kong, W., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., Wang, Yes, Wang, Z., Yes, S., Pan, H., Wang, S., Wu, J., Wang, Y., Li, Z., Liu, J., and Jiang, J. D. Berberine is a new drug that decreases cholesterol by working through a different mechanism. Nat Med 2004;10(12):1344-1351. See summary. Krol R, Zalewski A, and Maroko PR. Side effects of berberine, a new positive inotropic agent, in ventricular arrhythmias induced by digitalis. Circulation 1982;66(suppl 2):56. Ksiezycka E, Cheung W, and Maroko PR. Antiarrhythmic effects of berberine in ventricular and supraventricular arrhythmias induced by aconitin. Clinical Research 1983;31(2):197A. Kulkarni, S. K., Dandiya, P. C., and Varandani, N. L. Pharmacological investigations of berberine sulphate. Jpn.J Pharmacol. 1972;22(1):11-16. See summary. Kuo, C. L., Chi, C. W. and Liu, T. Y. Modulation of apoptosis by berberine through inhibition of cyclooxygenase-2 and Mcl-1 expression in oral cancer cells. In Vivo 2005;19(1):247-252. See summary. Kuo, C. L., Chou, C. and Yung, B. Y. Berberine complexes with DNA in the berberine-induced apoptosis in human leukemic HL-60 cells. Cancer Lett 7-13-1995;93(2):193-200. See summary. Lahiri S and Dutta NK. Berberine and chloramphenicol in the treatment of cholera and severe diarrhea. Journal of the Indian Medical Association 1967;48(1):1-11. Lamb, J. J., Holick, M. F., Lerman, R. H., Konda, V. R., Minich, D. M., Desai, A., Chen, T. C., Austin, M., Kornberg, J., Chang, J. L., Hsi, A., Bland, J. S., and Tripp, M. L. acid supplement 2011 biono See summary. Lau, C. W., Yao, X. Q., Chen, Z. Y., Ko, W. H., and Huang, Y. Cardiovascular actions of berberine. Cardiovasc Drug Rev 2001;19(3):234-244. See summary. Lee, S., Lim, H. J., Park, H. Y., Lee, K. S., Park, J. H. and Jang, Y. Berberine inhibits the proliferation of smooth muscle cells and in vitro migration and improves neo-intimate formation after in vivo balloon injury. Berberine improves neo-intimate formation in a rat model. Atherosclerosis 2006;186(1):29-37. See summary. Li XB. [Clinical controlled trial in infants and children who compare Lacteol Fort scarlets with two antidiarrheal reference drugs]. Ann Pediatr 1995;42(6):396-401. Li, G. H., Wang, D.L., Hu, Y. D., Pu, P., Li, D. Z., Wang, W. D., Zhu, B., Hao, P., Wang, J., Xu, X. Q., Wan, J. Q., Zhou, Y. B. and Chen, Z. T. Berberine inhibits acute human radiation intestinal syndrome with abdominal radiation therapy. Med Oncol. 2010;27(3):919-925. See summary. Li, H., Miyahara, T., Tezuka, Y., Namba, T., Suzuki, T., Dowaki, R., Watanabe, M., Nemoto, N., Tonami, S., Seto, H., and Kadota, S. The effect of kampo formulas on in vitro and in vivo bone resorption. II. Detailed study of Berberine. Biol Pharm Bull 1999;22(4):391-396. See summary. Lin, C. C., Kao, S. T., Chen, G. W., Ho, H. C., and Chung, J. G. Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3. Anticancer Res 2006;26(1A):227-242. See summary. Lin, J. G., Chung, J. G., Wu, L. T., Chen, G. W., Chang, H. L. and Wang, T. F. Effects of berberine on arylamine N-acetilransferase activity in human colon tumor cells. Am J Chin Med 1999;27(2):265-275. See summary. Lin, J. P., Yang, J. S., Lee, J. H., Hsieh, W. T. and Chung, J. G. Berberine induces the arrest of the cell cycle and apoptosis in human gastric carcinoma SNU-5. World J Gastroenterol. 1-7-2006;12(1):21-28. See summary. Lin, S., Tsai, S. C., Lee, C. C., Wang, B. W., Liou, J. Y., and Shyu, K. G. Berberine inhibit the expression HIF-1alpha through improved proteolisis. Mol Pharmacol 2004;66(3):612-619. See summary. Liu, Yes, Yu, H., Zhang, C., Cheng, Y., Hu, L., Meng, X., and Zhao, Y. Protective effects of berberine on radiation-induced lung lesions by molecular intercellular adherence-1 and transformative-beta-1 growth factor in patients with lung cancer. Eur J Cancer 2008;44(16):2425-2432. See summary. Lu, S. S., Yu, Y. L., Zhu, H. J., Liu, X. D., Liu, L., Liu, Y. W., Wang, P., Xie, L., and Wang, G. J. Berberine promotes the secretion of amida in diabetic rats induced by streptozotocin. J Endocrinol. 2009;200(2):159-165. See summary. Mahajan, V. M., Sharma, A. and Rattan, A. Antimicotic activity of Berber sulfate: an alkaloid of an Indian medicinal herb. Sabouraudia. 1982;20(1):79-81. See summary. Mantena, S. K., Sharma, S. D., and Katiyar, S. K. Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3- dependent apoptosis in human prostate carcinoma cells. Ther mold cancer 2006;5(2):296-308. See summary. Marazzi, G., Cacciotti, L., Pelliccia, F., Iaia, L., Volterrani, M., Caminiti, G., Sposato, B., Massaro, R., Grieco, F., and Rosano, G. Long-term effects of nutraceutics (berine, red yeast rice, polycosanol) in hypercolesterol patients. Adv.Ther 2011;28(12):1105-1113. See summary. Marin-Neto, J. A., Maciel, B. C., Secches, A. L. and Gallo, Junior L. Cardiovascular effects of berberine in patients with severe congestive heart failure. Clin.Cardiol. 1988;11(4):253-260. See summary. Meng, S., Wang, L. S., Huang, Z. Q., Zhou, Q., Sun, Y. G., Cao, J. T., Li, Y. G. and Wang, C. Q. Berberine ameliorates inflammation in patients with acute coronary syndrome after percutaneous coronary intervention. Clin Exp.Pharmacol Physiol 2012;39(5):406-411. See summary. Mitani, N., Murakami, K., Yamaura, T., Ikeda, T. and Saiki, I. Inhibitory effect of berberine in the mediastinal metastases of lymph nodes produced by orthotopic implant of Lewis' pulmonary carcinoma. Cancer Lett. 4-10-2001;165(1):35-42. See summary. Miyazaki, H., Shirai, E., Ishibashi, M., Hosoi, K., Shibata, S. e Iwanaga, M. Quantitation of berberine chloride in human urine by use of selected ion monitoring in the field desorption mode. Biomed. Mass spectrom. 1978;5(10):559-565. See summary. Mohan, M., Pant, C. R., Angra, S. K. and Mahajan, V. M. Berberine in trachoma. (Clinical trial). Indian J Ophthalmol. 1982;30(2):69-75. See summary. Muller, K., Ziereis, K. and Gawlik, I. Mahonia's anti-psyriatic acufolio and its active components; II. Anti-proliferative activity against cell growth of human keratinocytes. Med Plant 1995;61(1):74-75. See summary. Ni, Y. X. [Therapeutic effect of berberine in 60 patients with type II diabetes mellitus and experimental research]. Zhong. Xi.Yi.Jie. He.Za Zhi.- Chinese Journal of Modern Developments in Traditional Medicine 1988;8(12):711-3, 707. See summary. Ni, Y. X., Yang, J., and Fan, S. [Clinical study on jiang tang san in the treatment of patients with diabetes mellitus not insulin-dependent]. Zhongguo Zhong.Xi.Yi.Jie. He.Za Zhi. 1994;14(11):650-652. See summary. Nishida, S., Kikuichi, S., Yoshioka, S., Tsubaki, M., Fujii, Y., Matsuda, H., Kubo, M. e Irimajiri, K. Induction of apoptosis in HL-60 cells treated with medicinal herbs. Am J Chin Med 2003;31(4):551-562. See summary. Ozaki, Y., Suzuki, H., and Satake, M. [Comparative studies on the concentration of berberine in plasma after the oral administration of the extract of coptidis rhizoma, its extract of cultivated cells and the combined use of these extracts and extract of ráx glicirizae in rats]. Yakugaku Zasshi 1993;113(1):63-69. See summary. Palasuntheram C, Iyer KS, de Silva LB, and et al. Antibacterial activity of Coscinium fenestratum Colebr against Clostridium tetani. Ind J Med Res 1982;76(Supl):71-76. Pan, J. F., Yu, C., Zhu, D. Y., Zhang, H., Zeng, J. F., Jiang, S. H. and Ren, J. Y. Identification of three metabolites combined with berberine chloride sulfate in urine of healthy volunteers after oral administration. Acta Pharmacol Sin. 2002;23(1):77-82. See summary. Peng, W. H., Hsieh, M. T. and Wu, C. R. Effect of the long-term administration of Berberine in amnesia induced by schoolamine in rats. Jpn J Pharmacol 1997;74 (3):261-266. See summary. Pisciotta, L., Bellocchio, A. and Bertolini, S. Nutraceutical pill containing berberine versus ezetimibe on plasma lipid pattern in hypercholesterolemic subjects and its additive effect in patients with familial hypercholesterolemia on stable cholesterol-lowering treatment. Lipids Health Dis 2012;11:123. See summary. Purohit SK, Kochar DK, Lal BB and et al. Cultivation of tropic Leishmania of untreated cases and treated of oriental pain. Indian Journal of Public Health 1982;26(1):34-37. Rabbani G. Mechanism and treatment of diarrhea by Vibrio cholerae and Escherichia coli: drug and prostaglandin roles. Danish Medical Bulletin 1996;43:173-185. Sabir M and Bhide NK. Study of some pharmacological actions of the Berberine. Ind J Physiol & Pharmac 1971;15(3):111-132. Sabir M, Mahajan VM, Mohapatra LN, and et al. Experimental study of the antitracoma action of Berberine. Indian J Med Res 1976;64(8):1160-1167. Sack, R. B. and Froehlich, J. L. Berberine inhibits the secret intestinal response of enterotoxins Vibrio cholerae and Escherichia coli. Infect Immun. 1982;35(2):471-475. See summary. Saksena HC, Take VN and Soangra MR. Effectiveness of a new salt of Berberina Uni-Berberine in the eastern ulcer. Current medical practice 1970;14:247-252. Seery TM and Bieter RN. A contribution to Berberine pharmacology. J Pharmacol Exp Ther 1940;69:64-67. Seow WK, Ferrante A, Summors A, and et al. Comparative effects of tetrandrin and berbamine in the production of the inflammatory factor of interleukin-1 cytokines and tumor necrosis. Life Sciences 1992;50(8):pl-53-pl-58. Shaffer, J. E. Inotropic and chronotropic activity of berberine on isolated guinea pig atria. J Cardiovasc Pharmacol 1985;7(2):307-315. See summary. Shanbhag, S. M., Kulkarni, H. J., and Gaitonde, B. B. Pharmacological actions of berberine on the central nervous system. Jpn.J Pharmacol 1970;20(4):482-487. See summary. Sharda DC. Berberine in the treatment of childhood and childhood diarrhea. J Indian M A 1970;54(1):22-24. Sharma R, Joshi CK and Goyal RK. Berberian tannate in acute diarrhea. Indian Pediatrics 1970;7(9):496-501. Soffar, S. A., Metwali, D. M., Abdel-Aziz, S., the Wakil, H. S., and Saad, G. A. Evaluation of the effect of an alkaloid plant (beberine derived from Berberis aristata) in Trichomonas vaginalis in vitro. J Egypt. Soc Parasitol. 2001;31(3):893-904. See summary. Sriwilaijareon, N., Petmitr, S., Mutirangura, A., Ponglikitmongkol, M., and Wilairat, P. Specificity of the Plasmodium falciparum telomerase stage and its berberine inhibition. Parasitol. Int 2002;51(1):99-103. See summary. Subbaiah TV and Amin AH. Effect of Berberine sulfate in Entamoeba histolytica. Nature 1967;215(100):527-528. Sun D, Courtney HS and Beachey EH. Berberin sulfate blocks the adherence of Streptococcus piogens to epithelial cells, fibronectin and hexadean. Antimicrobian Agents and Chemotherapy 1988;32(9):1370-1374. Supek Z and Tomic D. Farmakološko-kemijsko istrazivanje zutike (Swabb, E. A., Tai, Y. H., and Jordan, L. Reversal of cholera toxin-induced secretion in rat ileum by luminal berberine. Am J Physiol 1981;241(3):G248-G252. See summary. Tai, Y. H., Feser, J. F., Marnane, W. G. and Desjeux, J. F. Anti-secretary effects of the Berberine on the rats' icon. Am J Physiol 1981;241(3):G253-G258. See summary. Thumm, H. W. and Tritschler, J. [The action of the Berberin outbreaks on intraocular pressure (IOP) (transl of the author)]. Klin.Monbl.Augenheilkd. 1977;170(1):119-123. See summary. Trimarco, V., Cimmino, C. S., Santoro, M., Pagnano, G., Manzi, M. V., Piglia, A., Giudice, C. A., De, Luca N. e Izzo, R. Nutraceuticals for blood pressure control in patients with high-normal or grade 1 hypertension. High blood pressure cardiovasc. Prev. 9-1-2012;19(3):117-122. See summary. Tripathi YB and Shukla SD. Berberis artist inhibits PAF's induced aggregation of rabbit platelets. Research of Physiotherapy 1996;10:628-630. Vik-Mo H, Faria DB, Cheung WM, and et al. Berberine effects in left ventricular function in dogs with heart failure. Clinical Research 1983;31(2):224a. Wang, D. Y., Yeh, C. C., Lee, J. H., Hung, C. F. and Chung, J. G. Berberine inhibited arilamine N-acetilransferase activity and gene expression and the formation of DNA aqueducts in human malignant astrocytoma (G9T/VGH) and cerebral glioblastoma cells 8401. Neurochem. Res 2002;27(9):883-889. See summary. Wang, N., Feng, Y., Cheung, F., Chow, O. Y., Wang, X., Su, W. and Tong, Y. Comparative study on hepatoprotector action of bear bile and aqueous extract of Coptidis Rhizoma on experimental liver fibrosis in rats. BMC.Complement Altern.Med 2012;12:239. See summary. Wang, Q., Zhang, M., Liang, B., Shirwany, N., Zhu, Y., and Zou, M. H. The activation of protein kinase activated by AMP is necessary for the reduction of berberine-induced atherosclerosis in mice: the role of non-friing protein 2. PLoS.One. 2011;6(9):e25436. See summary. Wang, Y., Jia, X., Ghanam, K., Beaurepaire, C., Zidichouski, J., and Miller, L. Berberine and plant statanols synergize cholesterol absorption in hamsters. Atherosclerosis 2010;209(1):111-117. See summary. Wei, W., Zhao, H., Wang, A., Sui, M., Liang, K., Deng, H., Ma, Yes, Zhang, Y., Zhang, H., and Guan, Y. Clinical study on the short-term effect of berberine compared to metformin on the metabolic characteristics of women with polycystic ovarian syndrome. Eur J Endocrinol. 2012;166(1):99-105. See summary. Wright, C. W., Marshall, S. J., Russell, P. F., Anderson, M., Phillipson, J. D., Kirby, G. C., Warhurst, D. C., and Schiff, P. L. Antiplasmodial, antiamoemoccal and cytotoxic activities of some monomeric isochinoline alkaloids. J Nat Prod 2000;63(12):1638-1640. See summary. Wu, H.L., Hsu, C. Y., Liu, W. H. and Yung, B. Y. Berberin-induced apoptosis of human leukemia HL-60 cells is associated with the low regulation of nucleophosmin/B23 and the theomerase activity. Int J Cancer 6-11-1999;81(6):923-929. See summary. Wu, J. F. and Liu, T. P. [Berberine effects on platelets and plasma levels of TXB2 and alpha 6-keto-PGF1 in rats with occlusion of reversible middle cerebral artery]. Yao Xue.Xue.Bao. 1995;30(2):98-102. See summary. Wu, S. N., Yu, H. S., Jan, C. R., Li, H. F. and Yu, C. L. Inhibitory effects of berberine on potassium currents activated by voltage and calcium in human myeloma cells. Life Sci 1998;62(25):2283-2294. See summary. Xin, H. W., Wu, X. C., Li, Q., Yu, A. R., Zhong, M. Y., and Liu, Y. Y. The effects of berberine on pharmacokinetics of cyclosporine A on healthy volunteers. Methods Find.Exp.Clin Pharmacol 2006;28(1):25-29. See summary. Xu, M. G., Wang, J. M., Chen, L., Wang, Y., Yang, Z. and Tao, J. Berberine-induced mobilization of circulating endothelial parent cells improves human small artery elasticity. J Hum.Hypertens 2008;22(6):389-393. See summary. Yang, Z., Shao, Y. C., Li, S. J., Qi, J. L., Zhang, M. J., Hao, W., and Jin, G. Z. The drug of l-tetrahydropalmatin considerably improves the desire for opiates and increases the abstinence rate in heroin users: a pilot study. Acta Pharmacol Sin. 2008;29(7):781-788. See summary. Yin, J., Xing, H. and Ye, J. Berberin effectiveness in patients with type 2 diabetes mellitus. Metabolism 2008;57(5):712-717. See summary. Yount, G., Qian, Y., Moore, D., Basila, D., West, J., Aldape, K., Arvold, N., Shalev, N., and Haas-Kogan, D. Berberine sensitizes human glioma cells, but not normal glyal cells, to ionize in vitro radiation. J Exp Ther Oncol. 2004;4(2):137-143. See summary. Yuan, J., Shen, X. Z., and Zhu, X. S. [The effect of berberine in the transit time of the human small intestine]. Zhongguo Zhong.Xi.Yi.Jie. He.Za Zhi. 1994;14(12):718-720. See summary. Zalewski A, Krol R and Maroko PR. Berberine, a new inotropic agent - distinction between his heart and peripheral responses. Clin 1983 Res;31(2):227A. Zeng, X. and Zeng, X. Relation between the clinical effects of berberine on severe congestive heart failure and its plasma concentration studied by HPLC. Biomedical Cromatogr 1999;13(7):442-444. See summary. Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z., Wang, S. K., Zhou, Z. X., Song, D. Q., Wang, Y. M., Pan, H. N., Kong, W. J., and Jiang, J. D. Berberine reduces blood metacosa in 2010 See summary. Zhang, M. F. and Shen, Y. Q. [Anti-diarrheal and anti-inflammatory effects of Berberine]. Zhongguo Yao Li Xue.Bao. 1989;10(2):174-176. See summary. Zhang, Yes, Li, X, Zou, D., Liu, W., Yang, J., Zhu, N., Huo, L., Wang, M., Hong, J., Wu, P., Ren, G. and Ning, G. Treatment of diabetes and type 2 dyslipemia with natural plant alkaloid berberine. J Clin Endocrinol. Metab 2008;93(7):2559-2565. See summary. Zhou, J. Y., Zhou, S. W., Zhang, K. B., Tang, J. L., Guang, L. X., Ying, Y., Xu, Y., Zhang, L., and Li, D. Chronic effects of berberin in blood, metabolism of liver glucolipid and expression of the liver PPARs in diamic rats. Biol Pharm Bull. 2008;31(6):1169-1176. See summary. Zhu B and Ahrens FA. Effect of berberine in the intestinal secretion mediated by the enterotoxin of heat Escherichia coli in syjunum of pigs. Am J Vet Res 1982;43(9):1594-1598. Zhu, B. and Ahrens, F. Antisecretary effects of Berberine with morphine, clonidine, L- phenylene, yohimbina or neostigmina in pork jejunum. Eur J Pharmacol 12-9-1983;96(1-2):11-19. See summary. Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. AMPK Activation: A therapeutic target for type 2 diabetes? Diabetes Metab Syndr Obesities 2014;7:241-53. See summary. Abascal K, Yarnell E. Recent clinical developments with Berberine. Altern Complement Ther 2010;16(5):281-7. Amin AH, Subbaiah TV, Abbasi KM. Berber sulfate: antimicrobial activity, bioassay and mode of action. May J Microbiol 1969;15:1067-76. See summary. An Y, Sun Z, Zhang Y, Liu B, Guan Y, Lu M. The use of berberine for women with polycystic ovarian syndrome undergoing IVF treatment. Clin Endocrinol (Oxf) 2014;80(3):425-31. See summary. Ang ES, Lee ST, Gan CS, et al. Evaluate the role of alternative therapy in managing burn wounds: randomized trial that compares the ointment of wet exposed burns with conventional methods in the management of patients with second-degree burns. MedGenMed 2001;3:3. See summary. Anis KV, Rajeshkumar NV, Kuttan R. Inhibition of chemical carcinogenesis by berberine in rats and mice. J Pharm Pharmacol 2001;53:763-8. . See summary. Asbaghi O, Ghanbari N, Shekari M, et al. The effect of berberin supplementation in the parameters of obesity, inflammation and liver function enzymes: systematic review and metaanalysis of randomized controlled trials. Clin Nutr ESPEN 2020;38:43-9. See summary. Beba M, Djafarian K, Shab-Bidar S. Effect of Berberine on C-reactive protein: a systematic review and meta-analysis of randomized controlled trials. Complement Ther Med. 2019;46:81-6. See summary. Bhide MB, Chavan SR, Dutta NK. Absorption, distribution and excretion of Berberine. Indian J Med Res 1969;57:2128-31. See summary. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome inhibition P450 3A4 by selected commercial herbal extracts and stains. Fitomedicine 2000;7:273-82. See summary. Butcher NJ, Minchin RF. Arylamine N-acetyltransferase 1: a new drug target in the development of cancer. Pharmacol Rev 2012;64(1):147-65. See summary. Chan E. Displacement of bilirubin de albumin by berberine. Biol Neonate 1993;63:201-8. See summary. Chatterjee P, Franklin MR. Inhibition of human cytochrome p450 and complex metabolic-intermediate formation by extract of gold and its components of methylenedioxyphenyl. Drug metastasis disorder 2003;31:1391-7. See summary. Chen C, Tao C, Liu Z, Lu M, Pan Q, Zheng L, et al. A randomized clinical trial of Berberin hydrochloride in patients with irritable bowel syndrome predominantly diarrhea. Phytother Res. 2015 Nov;29(11):1822-7. doi: 10.1002/ptr.5475. See summary. Chen YX, Gao QY, Zou TH, et al. Berberine versus placebo for the prevention of the recurrence of colorectal adenoma: a multicentered, double-blind and randomized controlled study. Lancet Gastroenterol Hepatol. 2020;5(3):267-75. See summary. Cicero, AF, Rovati LC and Setnikar I. Eulipidic effects of berberine administered alone or in combination with other natural cholesterol reduction agents. A unique blind clinical investigation. Arzneimittelforschung. 2007;57:26-30. See summary. Dong H, Zhao Y, Zhao L, Lu F. The effects of berberine on blood lipids: a systemic review and metaanalysis of randomized controlled trials. Med Plant 2013;79(6):437-46. See summary. Fukuda K, Hibiya Y, Mutoh M, et al. Brberine inhibition of cycloxygenous transcriptional activity-2 in human colon cancer cells. J Ethnopharmacol 1999;66:227-33. See summary. Garber AJ. Long-acting peptide receptor agonists: a review of its effectiveness and tolerability. Diabetes care 2011;34 Suppl 2:S279-84. See summary. Gupte S. Use of Berberine in treatment of giardiasis. Am J Dis Child 1975;129:866. See summary. Hou Q, Han W, Fu X. Pharmacokinetic interaction between tacrolimus and berberine in a child with idiopathic nephrotic syndrome. Eur J Clin Pharmacol 2013;69(10):1861-2. See summary. Hsiang CY, Wu SL, Cheng SE, Ho TY. The production of acetaldehyde induced by interleukin-1beta and tumor necrosis factor-alpha is inhibited by berberine through nuclear factor-kappa B signaling path in HepG2 cells. J Biomed Sci 2005;12:791-801. See summary. Huang CG, Chu ZL, Wei SJ, Jiang H, Jiao BH. Effect of berberine in the metabolism of arachidonic acid in rabbit platelets and endothelial cells. Thromb Res 2002;106(4-5):223-7. See summary. Huang XS, Yang GF, Pan Yes. Effect of berberine hydrochloride in blood cyclosporine A concentration in patients with heart transplantation. Zhongguo Zhong Xi Yi Jie He Za Zhi 2008;28:702-4. See summary. Ivanovska N, Philipov S. Study on the anti-inflammatory action of the Berberis vulgaris root extract, alkaloid fractions and pure alkaloids. Int J Immunopharmacol 1996;18:553-61. See summary. Janbaz KH, Gilani AH. Studies on the preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Physiotherapy 2000;71:25-33. See summary. Jiang XW, Zhang Y, Zhu YL, et al. Effects of Berberine jelly on recurrent aftopic stematitis: a randomized, placebo-controlled trial, double-blind in a Chinese cohort. Oral Surg Oral Med Oral Pathol Oral Radiol 2013;115(2):212-7. See summary. Ju J, Li J, Lin Q, Xu H. Berberine efficiency and safety for dyslipidemias: Systematic review and metaanalysis of randomized clinical trials. Fitomedicine. 2018;50:25-34. See summary. Kaneda Y, Torii M, Tanaka T, Aikawa M. In vitro effects of berberine sulfate on the growth and structure of the histolytics of Entamoeba, Giardia lamblia and Trichomonas vaginalis. Ann Trop Med Parasitol 1991;85:417-25. See summary. Khosla PG, Neeraj VI, Gupta SK, et al. Berberine, a potential drug for the trachoma. Rev Int Trach Pathol Ocul Trop Subtrop Sante Publique 1992;69:147-65. See summary. Kim JS, Tanaka H, Shoyama Y. Immunoquantitative analysis for berberine and its related compounds using monoclonal antibodies in herbal medications. Analyst 2004;129:87-91. See summary. Kim SH, Shin DS, Oh MN, et al. Protein inhibition of the bacterial surface by anchoring transpeptidase isochinoline alkaloids. Biosci Biotechnol Biochem 2004;68:421-4. See summary. Lan J, Zhao Y, Dong F, et al. Metaanalysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipidemia and hypertension. J Ethnopharmacol. 2015;161:69-81. See summary. Li B, Shang JC, Zhou QX. [Study of total alkaloids of rizoma coptis chinensis on experimental gastric ulcers]. Chin J Integr Med 2005;11:217-21. See summary. Li G, Zhao M, Qiu F, Sun Y, Zhao L. Pharmacokinetic interactions and tolerability of berberine chloride with simvastatin and phenophibrate: an open, randomized and parallel study in healthy Chinese subjects. Drug Des Devel Ther. 2018;13:129-139. See summary. Lyu Y, Zhang Y, Yang M, et al. Pharmacokinetic interactions between metformin and berberine in rats: Function of oral and microbiota management sequences. Life Sci. 2019;235:116818. See summary. Marazzi G, Campolongo G, Pelliccia F, Quattrino S, Vitale C, Caccio L, et al. Comparison of low-dose statin versus low-dose statin + Armolipida plus in high-intolerant statin patients with a previous coronary event and percutaneous coronary intervention (ADHERENCE test). Am J Cardiol. 2017 Sep 15;120(6):893-897. doi: 10.1016/j.amjcard.2017.06.015. See summary. Marazzi G, Pelliccia F, Campolongo G, Quattrino S, Cacciotti L, Volterrani M, et al. Nutraceutical Utility (Armolipid Plus) versus ezetimibe and combination in patients with dyslipidemia with coronary heart disease. Am J Cardiol. 2015 Dec 15;116(12):1798-801. doi: 10.1016/j.amjcard.2015.09.023. See summary. Millán J, Cicero AF, Torres F, Anguera A. Effects of a nutraceutical combination containing Berberine (BRB), polycosanol and red yeast rice (RYR), in lipid profile in hypercholesterolemic patients: A metaanalysis of randomized controlled trials. Clin Investig Arterioscler. 2016;28(4):178-87. See summary. Park KS, Kang KC, Kim JH, et al. Differential effects of protoberins in sterile and chitin biosynthesis in Candida albicans. J Antimicrob Chemother 1999;43:667-74. See summary. Pérez-Rubio KG, González-Ortiz M, Martínez-Abundis E, Robles-Cervantes JA, Espinel-Bermúdez MC. Effect of Berberine administration on metabolic syndrome, insulin sensitivity and insulin secretion. Metab Syndr Relat Disord 2013;11(5):366-9. See summary. Qing Y, Dong X, Hongli L, Yanhui L. Berberine promoted the myocardial protection of postoperative patients by regulating myocardial autophagia. Biomed Pharmacother. 2018;105:1050-1053. See summary. Rabbani GH, Butler T, Knight J, et al. Random controlled trial of berberine sulfate therapy for diarrhea due to Escherichia coli enterotoxogen and Vibrio cholera. J Infect Dis 1987;155:979-84. See summary. Rehman J, Dillow JM, Carter SM, et al. Increased production of G and M immunoglobulins specific to antigen after in vivo treatment with Echinacea angustifolia and Hydrastis canadensis medicinal plants. Immunol Lett 1999;68:391-5. See summary. Ruscica M, Gomaraschi M, Mombelli G, Macchi C, Bosisio R, Pazzucconi F, Pavanello C, Calabresi L, Arnoldi A, Sirtori CR, Magni P. Nutraceutical approach to moderate cardiometabolic risk: results of a randomized, double-blind and crossover study with Armolipid Plus. J Clin Lipidol. 2014;8(1):61-8. See summary. Scazzocchio F, Corneta MF, Tomassini L, Palmery M. Antibacterial activity of the extract of hydrstis canadensis and its main isolated alkaloids. Med Plant 2001;67:561-4. See summary. Sheng WD, Jiddawi MS, Hong XQ, Abdulla SM. Treatment of chlorokin-resistant malaria by pirimetamine in combination with Berberine, tetracycline or cotrimoxazole. East Afr Med J 1997;74:283-4. See summary. Sun D, Abraham SN, Beachey EH. Influence of Berberin sulfate in synthesis and expression of fimbrial papist adhesives in Escherichia coli uropatogennica. Antimicrob Agents Chemother 1988;32:1274-7. See summary. Sun D, Courtney HS, Beachey EH. Berberin sulfate blocks the adherence of Streptococcus piogens to epithelial cells, fibronectin and hexadean. Antimicrob Agents Chemother 1988;32:1370-4. See summary. Tsai PL, Tsai TH. Berberine hepatobiliary Excretion. Medications Metab Dispos 2004;32:405-12. . See summary. Vollekova A, Kost'alova D, Kettmann V, Toth J. Antifungal activity of the Mahonia acufolio extract and its main protoberine alkaloids. Fitother Res 2003;17:834-7. See summary. Wen C, Wu L, Fu L, Zhang X, Zhou H. Berberine improves tamoxifen tumor activity in drug-sensitive and drug-resistant MCF 7/TAM cells. Mol Med Rep. 2016;14(3):2250-6. See summary. Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine in the blood concentration of cyclosporine A in renal transplant receptors: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. See summary. Wu XK, Wang YY, Liu JP, Liang RN, Xue HY, Ma HX, et al. Random controlled test of letrozole, berberine or a combination for infertility in polycystic ovarian syndrome. Steril Fertil. 2016;106(3):757-765.e1. doi: 10.1016/j.fertnstert.2016.05.022. See summary. Xie, X., Meng, X, Zhou, X., Shu, X., and Kong, H. [Investigation on the therapeutic effect and change of berberine hemorreology in new patients diagnosed with type 2 diabetes that combines nonalcoholic fat liver disease]. Zhongguo Zhong Yao Za Zhi 2011;36(21):3032-3035. See summary. Xu L, Zhang Y, Xue X, et al. A Berberine trial in Chinese with ulcerative colitis. Cancer Prev Res (Phila). 2020;13(1):117-26. See summary. Yan HM, Xia MF, Wang Y, Chang XX, Yao XZ, Rao SX, et al. Berberine effectiveness in patients with non-alcoholic liver disease. PLoS One. 2015 Aug 7;10(8):e0134172. doi: 10.1371/journal.pone.0134172. See summary. Zeng XH, Zeng XJ, Li YY. Efficacy and safety of Berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 2003;92:173-6. See summary. Zhang D, Ke L, Ni Z, Chen Y, Zhang LH, Zhu SH, et al. Berberine containing quadruple therapy for the initial eradication of Helicobacter pylori: A randomized phase IV trial. Medicine (Baltimore). 2017;96(32):e7697. doi: 10.1097/MD.0000007697. See summary. Zhang LS, Zhang JH, Feng R, et al. Effectiveness and safety of Berberine alone or combined with statins for the treatment of hyperlipidemia: systematic review and metaanalysis of randomly controlled clinical trials. Am J Chin Med 2019;47(4):751-67. See summary. Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93:2559-65. See summary. Select a condition to see a list of vitamins that may also take into account USE CONDITIONS AND IMPORTANT INFORMATION: This information is intended to complement, not replace the advice of your doctor or healthcare provider and is not intended to cover all possible uses, precautions, interactions or adverse effects. This information may not conform to your specific health circumstances. Never delay or contempt for professional medical advice from your doctor or other qualified health care provider due to something you've read on WebMD. You should always talk to your doctor or health care professional before you begin, stop or change any prescribed part of your plan or health treatment and determine which therapy course is suitable for you. USER CONDITIONS AND IMPORTANT INFORMATION: This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. The information of this source is based on evidence and objective, and without commercial influence. For professional medical information on natural medicines, see the professional version of the complete database of natural medicines. © Faculty of Therapeutic Research 2020. Today at WebMDRisky Mistakes Pet Owners Make Some of these might surprise you. Depressed, guilty feelings after eating? Symptoms of composture feeding disorder. Psoriasis Home Remedies14 tips to get rid of itching. Stop smoking Get your customized plan. Recommended for YouMultiple Sclerosis Symptoms10 Secrets to a Smile7 Ways You're missing your ADHD symptoms in children Type 2 diabetes Early warning signs What is schizophrenia? 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